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The co-occurrence of chronic pain and trauma symptoms is prevalent; thus treatment approaches that address both are required. This systematic review of non-randomized studies aims to describe available psychotherapeutic interventions that concurrently target chronic pain and trauma-related symptoms for adults. Five databases (MEDLINE, Embase, the Cochrane Central Register of Controlled Trials, the Cochrane Database of Systematic Reviews, PsycINFO) were searched from date of inception until...
CONCLUSIONS: hEDS patients had a higher psychiatric burden and psychoactive medication use than HSD patients, but ECG parameters largely remained within normal limits. The increased QTc prolongation in HSD patients highlights potential cardiovascular risks, requiring further investigation. Routine cardiovascular monitoring and interdisciplinary care are recommended for hypermobile patients on psychoactive medications.
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CONCLUSION: Open capsular shift with Achilles tendon allograft augmentation can be an effective procedure for restoring long-term shoulder stability and functionality in patients with MDI, including those with connective tissue disorders such as EDS.
CONCLUSIONS: the lower MCAS prevalence in SpA + EDS may reflect symptom overlap or suppression due to immunomodulatory treatments. Differences in medication use highlight variations in diagnostic and therapeutic strategies. Comprehensive evaluations are essential to ensure accurate diagnoses and optimal treatment approaches.
A 21-year-old woman with Ehlers-Danlos syndrome presented with symptomatic right renal mobility. Standing IV pyelogram demonstrated a 7 cm descent of the right kidney without hydronephrosis. She underwent a retroperitoneal single-port nephropexy without complications. At three months, imaging confirmed stable renal position with complete symptom resolution. This case highlights single-port robotic nephropexy as a safe and effective minimally invasive treatment with favorable short-term outcomes.
BACKGROUND: Defects in both CYP21A2 and TNXB genes cause congenital adrenal hyperplasia combined with hypermobility-type Ehlers-Danlos syndrome (EDS), which has been named CAH-X syndrome.
CONCLUSION: In this real-world cohort, CBMP treatment was associated with sustained improvements in outcomes for individuals with hypermobility-associated chronic pain. These findings support the need for further controlled studies to determine causality. Key Points • This 24-month real-world study demonstrates sustained improvements in pain, anxiety, and sleep outcomes for patients with hypermobility-associated chronic pain treated with cannabis-based medicinal products, with approximately 60%...
CONCLUSIONS: This scoping review maps age-related symptom/comorbidity clusters reported in pediatric hypermobility spectrum disorders, with the aim of informing earlier clinical recognition.
CONCLUSION: Specialized surgical interventions significantly improve long-term survival and reduce complications in MFS and EDS patients. Valve-sparing procedures, such as the David technique, represent gold standards for optimizing outcomes. Tailored surgical strategies, combined with advancements in imaging and structured follow-up protocols, are crucial for enhancing patient care. Future research should focus on multicenter trials and integrating genetic and molecular profiling to further...
Background: Hypermobile Ehlers-Danlos syndrome (hEDS), the most common EDS subtype, is characterized by chronic pain and joint laxity, yet no definitive causative genes or imaging-based diagnostic criteria have been established. This study investigated the genetic basis of hEDS using whole-exome sequencing (WES) and objectively evaluated ankle instability. Methods: We conducted an observational cohort study with a case-control comparison, including 22 patients and a three-generation Korean...
PURPOSE OF REVIEW: Hypertension in hypermobile Ehlers-Danlos syndrome (hEDS) and hypermobility spectrum disorders (HSD) represents an increasingly recognized but poorly understood clinical phenomenon. This review addresses the unique pathophysiology, diagnostic considerations, and management challenges of hypertension occurring in the context of dysautonomia - a comorbidity affecting up to 70% of patients with hEDS/HSD.
Chronic pain (CP) affects approximately 20% of children, significantly impacting their physical, emotional, and social well-being. Hypermobility disorders (HDs) are prevalent in pediatric populations, including those with CP, and often contribute to impairments in psychological and physical functioning. This study examined differences in sensory, functional, and neural circuitry among CP in youth with and without comorbid HD (CP + HD). Contrary to our a priori hypothesis and previous literature...
Ehlers-Danlos syndrome classical-like type 2 (clEDS2) is a rare autosomal recessive connective tissue disorder caused by biallelic loss-of-function variants in the gene encoding adipocyte enhancer-binding protein 1 (AEBP1). While cutaneous and skeletal manifestations are commonly observed, gastrointestinal complications, including bowel rupture, have been reported only rarely, and their histopathological basis remains poorly characterized. Here, we report findings of molecular investigations,...
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