SYNOPSIS:Patients with hypermobility spectrum disorders (HSD) and hypermobile Ehlers-Danlos syndrome (hEDS) frequently present to outpatient musculoskeletal practice. Yet many physical therapists feel uncertain about how best to manage these complex conditions. Individuals often report years of recurrent sprains, joint subluxations, widespread pain, and fatigue, accompanied by normal imaging and inconsistent clinical explanations. As a result, care may become fragmented, overly passive, or...
No abstract
Ehlers-Danlos syndromes (EDSs) are heritable connective tissue disorders caused by defects in collagen and related extracellular matrix proteins. Because the vocal fold (VF) lamina propria is a collagen-dependent structure, the voice might be expected to be affected, yet voice and laryngeal involvement has received comparatively little attention. This scoping review, conducted according to the Joanna Briggs Institute framework and reported following the PRISMA extension for Scoping Reviews...
BACKGROUND: Spontaneous coronary artery dissection (SCAD) is an important cause of acute coronary syndrome (ACS) in vascular Ehlers-Danlos syndrome (vEDS).
Multidirectional instability in patients with connective tissue disorders such as Ehlers-Danlos syndrome (EDS) is difficult to treat due to poor tissue quality and frequent failure of standard repairs. We describe an arthroscopic technique using gracilis tendon allografts to perform an anterior and posterior capsular augmentation in the revision setting with subscapularis deficiency. Allografts are anchored to the glenoid and humeral head in a sling configuration, restoring capsular restraint...
Clinical presentation and operative outcomes in vascular Ehlers-Danlos syndrome (VEDS) are heterogeneous. We present two patients with genetically confirmed VEDS who exhibited markedly different iliac pathology phenotypes. One ruptured a common iliac artery at a near-normal diameter and the other tolerated a large aortoiliac aneurysm without rupture. The Aortic and Arterial Vulnerability Spectrum is a conceptual framework that characterizes aortic and arterial failure (dissection/rupture) along...
Multidirectional shoulder instability, particularly in patients with underlying connective tissue disorders poses a surgical challenge. After exhaustive nonoperative treatment, surgical intervention is focused on restoration of the anterior and inferior capsular restraints. Oftentimes, after longstanding recurrent instability, the anterior capsule is diminutive with diffuse scarring and adhesions, requiring meticulous surgical dissection and allograft augmentation. Although outcome data are...
Hypermobile Ehlers-Danlos Syndrome (hEDS), characterized by joint hypermobility and multisystem involvement, is the most common type of EDS. Its comorbidities are wide-ranging, reflecting the involvement of connective tissue and its role in a multitude of processes. hEDS has been hypothesized to have hormonal aspects since the disorder is diagnosed more often in women and symptom changes closely correlate with hormonal shifts. To better understand the etiology and biochemical changes in hEDS and...
CONCLUSION: This case highlights the importance of multidisciplinary evaluation in differentiating benign from life-threatening subcutaneous emphysema to guide appropriate management and avoid unnecessary surgery.
Background: Ehlers-Danlos Syndrome (EDS) is a rare connective tissue disorder associated with substantial clinical complexity and healthcare utilization. Despite increasing recognition of EDS, little is known about its economic burden in the United States. Objective: To assess the all-cause healthcare costs for individuals with newly diagnosed EDS during the pre-diagnosis year and the first 2 years post-diagnosis. Methods: A retrospective cohort study was conducted using the Merativeâ„¢...
CONCLUSION: Familial CM-I is strongly associated with CTDs, particularly EDS, and systemic comorbidities such as hypermobility, postural orthostatic tachycardia syndrome, and mast cell activation disorder. These findings support a heritable link between CM-I and CTDs and highlight the importance of detailed family history and connective tissue evaluation in CM-I patients. Comprehensive assessment and counseling of at-risk relatives may improve diagnosis, surgical planning, and long-term...
PURPOSE OF REVIEW: Ehlers-Danlos syndrome (EDS) is a congenital connective tissue disorder that is often marked by chronic pain and considerable functional impairment. Pain in EDS is typically multifaceted, involving musculoskeletal, neuropathic, autonomic, and centralized pain components. The present investigation, therefore, aims to examine common pain phenotypes and mechanisms in EDS and to discuss strategies for interdisciplinary pain management briefly.
CONCLUSION: A substantial proportion of ED calls to poison centers involve children, some of whom experience severe neurologic and cardiac toxicity, among other symptoms. ED exposure calls are more common and have more medical severity than exposures to caffeine or coffee beans alone. The number and severity of adverse ED events warrant efforts to educate the public about the risks, especially in children.
Hypermobile Ehlers-Danlos Syndrome (hEDS) and Hypermobility Spectrum Disorders (HSD) are complex multisystemic conditions frequently associated with chronic pain. Central Sensitization (CS)-a state of neural amplification and hyperexcitability-is hypothesized to be a unifying mechanism underlying the heterogeneous symptoms in chronic pain patients. Our aim was to investigate the association between central sensitization and multisystemic symptom burden in patients with hEDS/HSD while identifying...
CONCLUSION: This is the first detailed clinical report of a Nusayri family in which a homozygous TNXB variant is associated with clEDS, and in which one heterozygous carrier presents with clinical features consistent with hEDS. Our findings contribute to the limited literature on clEDS, particularly in understudied populations. The clinical findings suggest the potential role of TNXB haploinsufficiency in hEDS; however, further research is needed to elucidate the variable expressivity and...
Get involved in the movement to help find answers faster through community sharing. #Sharingiscaring
Copyright © 2026 EDS Joint Effort. All rights reserved.