No abstract
CONCLUSIONS: In women diagnosed with vEDS prior to pregnancy, the absence of life-threatening vascular events suggests pregnancy may be safer than previously reported. These findings support more individualized counseling and underscore the need for further prospective studies.
CONCLUSION: With the newer, higher resolution, semirobotic biplane systems, IV 3D-DSA has become a tool in the angiography suite for rapid vascular assessment. It offers increased spatial resolution when compared with multidetector computed tomography, making it well suited to evaluate vasculature and endovascular devices, is noninvasive compared with catheter angiography, and can be used for intraoperative assessment of treatment.
CONCLUSIONS: This study is unique because we examine sex differences in sexual problems in patients with hEDS and HSD. Our findings indicate a higher percentage of sexual problems in females with hEDS than chronic pain controls without hypermobility, but this was not observed for females with HSD.
CONCLUSIONS: MVr can safely be performed in patients with CTD, with good short- and intermediate-term survival, as well as excellent durability. Mitral valve repair should be considered a standard of care in patients with connective tissue disease.
CONCLUSION: Dual-balloon-assisted coil and N-butyl cyanoacrylate (NBCA) embolisation enables precise, controlled flow arrest in high-flow SAA-SAVF, minimising non-target embolisation. This case highlights its value as a safe, spleen-preserving, and durable option-particularly relevant in patients with suspected connective-tissue disorders such as vEDS, where arterial fragility mandates meticulous endovascular technique.
CONCLUSIONS: Joint hypermobility, BPD symptoms, and autonomic dysfunction may be important factors when examining rates of NSSI and suicide attempts among individuals being assessed for EDS/G-HSD. Given the high prevalence of NSSI and suicide attempts observed, future research should continue to investigate mechanisms and examine the effectiveness of psychological interventions for this population.
Hypermobile Ehlers-Danlos syndrome (hEDS) is a hereditary connective tissue disorder characterized by generalized joint hypermobility, soft tissue fragility, chronic pain, and autonomic dysfunction. Although major vascular complications are uncommon in hEDS, affected individuals frequently undergo orthopedic procedures, including ligament reconstructions, tendon repair, and joint stabilization, due to recurrent dislocations and musculoskeletal injury. Consequently, careful evaluation of...
CONCLUSION: The high prevalence of dysautonomia in patients with chronic musculoskeletal painful conditions illustrates the association between dysautonomia and chronic pain, suggesting regular screening for dysautonomia is warranted for all patients with chronic musculoskeletal pain.
Patients with hypermobile Ehlers-Danlos syndrome (hEDS) have a higher reported prevalence of local anesthetic (LA) resistance and obstetric complications than the general population. We describe a 33-year-old G2P0010 ASA III parturient with a history of hEDS and lidocaine resistance who presented for an anesthesia consultation in anticipation of possible neuraxial anesthesia. We surmised that performing a neuraxial procedure would require effective skin infiltration of the patient's lumbar area....
Vascular Ehlers-Danlos syndrome (vEDS) is a rare connective tissue disorder characterized by type III collagen deficiency and marked vascular fragility, which can lead to atypical thoracic manifestations and diagnostic uncertainty. We report a 30-year-old man who initially presented with an ischemic stroke due to arterial dissection and was later diagnosed with vEDS following identification of a pathogenic COL3A1 variant. During follow-up, he developed a large cavitary lung lesion initially...
There is a large proportion of people living with chronic pain who also experience posttraumatic stress symptoms; however, there is no current standard treatment for addressing these mutually maintaining conditions. The aim of this systematic review and meta-analysis was to examine the efficacy of psychotherapeutic interventions for adults with chronic pain and trauma symptoms, where the effects of psychotherapy could be isolated. Systematic searches were conducted in 5 databases (MEDLINE,...
CONCLUSIONS: Phenotypes may constitute 1) different pathways for developing vulvodynia and/or 2) different subtypes of vulvodynia and/or EDS. We hypothesize that as a person accumulates comorbid conditions, their allostatic load increases, and once a personal allostatic load threshold is crossed, vulvodynia may develop.
Hypermobile Ehlers-Danlos Syndrome (hEDS) is a genetic connective tissue disorder characterized by hypermobile joints, chronic pain, fatigue, brain fog, orthostatic intolerance, and GI symptoms and dysmotility. Its heterogeneous presentation contributes to poor quality of life, inappropriate interventions, and prolonged diagnostic delays, often up to 10 years. This study primarily aimed to determine if physiological signals captured by a medical-grade wrist wearable could characterize autonomic...
Classical‑like Ehlers-Danlos syndrome (clEDS) due to TNXB variants is a hereditary connective tissue disorder that shares clinical features with classic EDS but differs genetically from the COL5A1/COL5A2‑associated cEDS subtype. The coexistence of inflammatory optic neuropathy and multiple nerve sheath tumors in this context is rarely reported. We describe a 26-year-old woman with genetically characterized clEDS (TNXB variant) who presented with subacute bilateral visual loss. Orbital magnetic...
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